Vitamin D and mortality may be a U-shaped curve

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  • Oponent? High dose A gives D deficiency. High dose D gives A deficiency. Carotene?
    No one knows the optimal A, D and optimal D / A. "All substances are toxic under the right conditions."(wiki) (Water, O2….)
    Christer Nylander

  • "High vitamin A intake has been associated with spontaneous bone fractures in animals. Cell culture studies have linked increased bone resorption and decreased bone formation with high intakes. This interaction may occur because vitamins A and D may compete for the same receptor and then interact with parathyroid hormone, which regulates calcium" (Wikipedia)

  • "Smokers and chronic alcohol consumers have been observed to have increased risk of mortality due to lung cancer, esophageal cancer, gastrointestinal cancer and colon cancer.[37] Hepatic (liver) injury has been found in human and animal studies where consumption of alcohol is paired with high dose vitamin A and beta-carotene supplementation."Wiki. They have shown: Toxic dose is toxic in some cases. What dose of A and D is optimal, in two-dimensions.A and D skydar against cancer, through p53.

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